Eliot Ness vs. assorted mobsters ( "The Untouchables," 1959-63, ABC): During the Prohibition era, federal agent Ness led his team of sleuths into showdowns with many of the most notorious -- and dangerous -- felons Chicago had.
U.N.C.L.E. vs. THRUSH ( "The Man From U.N.C.L.E.," NBC, 1964-68): Week in and week out, secret agents Napoleon Solo and Illya Kuryakin ( Robert Vaughn, David McCallum) battled clever enemies working for an organization bent on world domination.
Batman and Robin vs. the Riddler, the Joker, the Penguin, et al. ( "Batman," ABC, 1966-68): Gotham City's Caped Crusaders ( Adam West, Burt Ward) often were left in some trap they'd have to get out of the next night on the show.
J.R. Ewing vs. Cliff Barnes ( "Dallas," CBS, 1978-91): Continuing the feud that engulfed their fathers, and that resumes in this summer's TNT update, Cliff ( Ken Kercheval) was determined to destroy -- and was continually foiled by -- master schemer J.R. ( Larry Hagman).
Bo and Luke Duke vs. Boss Hogg ( "The Dukes of Hazzard," CBS, 1979-85): As long as the Duke cousins ( Tom Wopat, John Schneider) drove the General Lee, corrupt county boss Hogg ( Sorrell Booke) sought ways to foil them before they could bring him down.
Alexis vs. Blake ( "Dynasty," ABC, 1981-89): Ever vengeful toward oil tycoon and ex-husband Blake Carrington ( John Forsythe), Alexis ( Joan Collins) relished using her wealth and connections against him professionally and personally.
Jack Bauer vs. assorted terrorists ( "24," FOX, 2001-10): Whenever there was a plot against America, the resourceful Bauer ( Kiefer Sutherland) was called in to wade through murky alliances.
Clark Kent vs. Lex Luthor ( "Smallville," WB/CW, 2001-11): Initially friends, the young Clark ( Tom Welling) came to distrust privileged Lex ( Michael Rosenbaum) as Luthor's quest for power became increasingly evident.
Alicia Florrick vs. Louis Canning ( "The Good Wife," CBS, 2009-present): Alicia ( Julianna Margulies) always has to stay on her toes against cunning courtroom rival Canning ( Michael J. Fox), who never is above using his neurological condition as a sympathy ploy.
Photo/Video credit: ABC