Christina Applegate and Will Arnett in NBC's 'Up All Night': Watch the full series trailer

christina-applegate-up-all-night-320.jpg Christina Applegate and Will Arnett star in what looks like one of the more promising new comedies for the 2011-12 TV season, NBC's "Up All Night."

They play a couple who's been married for seven years and have just had their first child, which they quickly discover puts a major dent in their previous, not-quite-grown-up lifestyle. Maya Rudolph also stars.

Applegate, who's doing her first series since "Samantha Who?," is a new mom herself, having given birth to daughter Sadie in late January. Arnett also has two young children, so we're guessing they can relate to their roles pretty well.

The series will air at 8 p.m. ET Wednesdays in the fall. The show's trailer is below; more clips are here and here.

Photo/Video credit: NBC