House's favorite call girl is retiring, so he spends half the episode auditioning potential replacements. Then he spends some time trying to break up her impending marriage before he finds out she's not really retiring. She just thinks it's weird that he's married to someone he kind of likes but still brings her in. She recommends he try making a connection with his fake wife, so he ends up throwing away the letter from Immigration that says she can be a citizen.
In medical news, the patient of the week is Henry, a nice guy with a RealDoll he loves very much. That doesn't end up having anything to do with his illness, which he contracted by using tap water in a Neti Pot.