MTV VMAs 2011: Brian May joins Lady Gaga for 'You and I' to open the showAdd to Favorites | 2011 MTV Video Music Awards
The performance started with Gaga dressed as a man and giving a soliloquy about Lady Gaga being crazy and "who she is" as if she were this man talking about his ex-girlfriend. She then took to the piano for "You and I," which is a great song. But we'd almost fallen asleep during her spoken-word part.
Once the actual song started, it got very awesome, especially when Gaga was joined onstage by Queen guitarist Brian May. Was she channeling Billy Joel? That's a bit what it seemed like. Video below in case you missed it.