WATCH: Kelsey Grammer is the 'Boss' in new Starz series

In "Boss," his first dramatic television series, Kelsey Grammer ( "Frazier") plays Mayor Tom Kane, who sits at the center of Chicago politics and -- one way or another -- keeps his voter base happy. He's also hiding the fact that he's got a degenerative disorder that is slowly chipping away at his brain. This could get interesting.

In the 12-minute clip above -- that includes some interesting behind-the-scenes history -- we learn a little bit about Tom Kane; what makes him tick. We also meet his wife Meredith ( Connie Nielsen), who is in it strictly for the image. Advisers Kitty O'Neil ( Kathleen Robertson) and Ezra Stone ( Martin Donovan) don't really have any idea what's going on, but Kane's estranged daughter, played by Hannah Ware, may have a clue.

"Boss," a Starz original series, debuts on Friday, Oct. 21 at 10 p.m. ET.
Photo/Video credit: Starz