Another Hollywood couple has called it quits.

"40-Year-Old Virgin" actress Catherine Keener and "My Best Friend's Wedding" actor Dermot Mulroney are divorcing after 17 years of marriage, report celebrity news sources.

Mulroney filed for divorce on June 8 in Los Angeles Superior Court, citing "irreconcilable differences."

Keener, 48, and Mulroney, 43, met while filming "Survival Quest" in 1987 and were married three years later. They've been separated since May 2005 and have one son together, Clyde, 7.

The actor is seeking joint legal and physical custody of their son, and for the courts to determine property rights.

Keener has supporting actress Oscar nominations for "Being John Malkovich" and "Capote." She's most recognized now for "The 40-Year-Old Virgin" as the woman who deflowered Steve Carell's character. Mulroney currently stars opposite Lindsay Lohan in "Georgia Rule."

The couple costarred in 2001's "Lovely and Amazing" and co-produced "God Grew Tired of Us: The Story of Lost Boys of Sudan."