Bradley Cooper, Kevin Connolly, Justin Long, Jennifer Connelly and Ginnifer Goodwin are the first wave of actors trying to negotiate the world of dating.

The bevy of actors are in talks to star in the Drew Barrymore-produced and -starring comedy "He's Just Not That Into You," according to The Hollywood Reporter.

Based on the humorous book of the same name, "Into You" examines how modern-day men and women misinterpret each others' signals in dating relationships. The New Line Cinema film will be an ensemble comedy set in Baltimore and the interconnecting stories of various characters sending mixed signals to members of the opposite sex.

Barrymore stars as a woman confused by dating, especially since technology nowadays cuts down on face-to-face human contact.

In this tangled web, Jennifer Connolly's character is stuck in a stale marriage to Cooper's ("Alias") character, who in turn is having an affair with a lady yet to be cast. This woman in turn, is the object of affection for Kevin Connolly's ("Entourage") character. Completing this mess is Ginnifer Goodwin, who is obsessed with Connolly and tries to "accidentally" run into him, only to meet his friend played by Justin Long ("Live Free or Die Hard") who decides to play Henry Higgins to her Eliza Doolittle.

Ken Kwapis ("The Office," "The Sisterhood of the Traveling Pants") will direct. Production is scheduled to begin in early September in Los Angeles.