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Step 12: Stop having people sleep together just because
Most cited moment for when viewers lost interest in "Grey's Anatomy" once and for all? When Izzie and George (T. R. Knight) slept together.
Think it through before hooking up cast members randomly. What should this accomplish? Breaking up George's marriage? Helping Izzie get over Denny? Destroying a friendship? All of that could have been handled a hundred other ways.