'The Simpsons' to 'House': FOX's 25 best and most important shows of the last 25 years

(FOX)
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'The X-Files' (1993-2002)

Yes, things went downhill for the series after the first movie, and yes, some of the big questions the show raised were never answered, at least not satisfactorily. But "The X-Files" definitively proved that sci-fi could work in primetime, and when it was working at its highest level it was simply one of the best shows on TV, regardless of genre.
Apr. 20, 2012