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"House"-hold name: Mira Sorvino as Dr. Cate Milton.
"House"-lights: Cate is a doctor in Antarctica, whom House must treat via webcam. House has Cate and her colleague Sean perform many remote tests, including a self-administered lymph node sampling, drilling into her head and drinking her urine. In the end, Cate has had a broken big toe for months (causing an embolism) but could not tell because of the extreme cold. After resetting the toe, she is fine.
Out-"House": Mira Sorvino won the Best Supporting Actress Oscar for her work in "Mighty Aphrodite." This episode, which aired after the 2008 Super Bowl, is the highest-rated of the series.