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We don't know exactly what happened to Natalie Wood. She drowned while on a boat trip with her husband, Robert Wagner, and actor Christopher Walken. It was originally called an accident, but the LA County Coroner changed the ruling to "undetermined" in 2012.
What we do know is that her last movie was the sci-fi flick "Brainstorm" -- co-starring Christopher Walken. She died during a break in production, and a stand-in and sound alines ended up taking her place in some key scenes.