The charmed life of Vincent Chase may not be quite so charmed when "Entourage" returns to HBO in September.

The series makes its return on Sunday, Sept. 7, a year and five days after the last original episode aired. It will pick up more or less where last season left off, with Vince ( Adrian Grenier) and Co. struggling after the disastrous screening of "Medellin" at the Cannes Film Festival.

Manager Eric ( Kevin Connolly) is trying to get Vince back on top while expanding his own business, Ari ( Jeremy Piven) has his own problems at his agency and Turtle (Jerry Ferrara) is wondering where he fits in. The only member of the crew on an upswing is Drama (Kevin Dillon), whose TV career continues to flourish.

Per usual, "Entourage" will also feature a parade of guest stars this season. Among those appearing are Bow Wow, Lukas Haas and Giovanni Ribisi as clients of Eric's; "Gossip Girl" star Leighton Meester as Vince's new love interest; and Fran Drescher and Kevin Pollak as an annoying Beverly Hills couple. Carla Gugino, Martin Landau and Paul Ben-Victor will reprise their roles from the past.

Among the folks appearing as themselves are Jeffrey Tambor ("Arrested Development"), Jamie-Lynn Sigler ("The Sopranos"), Mark Wahlberg (who's also an executive producer of the series), Tony Bennett and golfer Phil Mickelson.