| 7:00 | 7:30 | 8:00 | 8:30 | 9:00 | 9:30 | |
| Sun | The OT | The Simpsons | King of the Hill | Family Guy | American Dad | |
| Mon | Terminator: The Sarah Connor Chronicles | Prison Break | ||||
| Tue | House | Fringe | ||||
| Wed | Bones | 'Til Death | Do Not Disturb | |||
| Thu | The Moment of Truth | Kitchen Nightmares | ||||
| Fri | Are You Smarter Than a Fifth Grader? | Don't Forget the Lyrics! | ||||
| Sat | Cops | Cops | America's Most Wanted: America Fights Back | |||
| 7:00 | 7:30 | 8:00 | 8:30 | 9:00 | 9:30 | |
| Sun | Comedy encores | Comedy encores | The Simpsons | King of the Hill (January) / Sit Down, Shut Up (spring) | Family Guy | American Dad (January) / The Cleveland Show (spring) |
| Mon | Dollhouse | 24 | ||||
| Tue | American Idol | Fringe | ||||
| Wed | House | American Idol results show | TBA comedy | |||
| Thu | Hell's Kitchen | Secret Millionaire | ||||
| Fri | Bones | 'Til Death | Do Not Disturb | |||
| Sat | Cops | Cops | America's Most Wanted: America Fights Back | |||
| Legend: | New Show | New Timeslot | Returning Show |