Comedian and sitcom actor Mike O'Malley will cross over to drama next fall in NBC's new series "My Own Worst Enemy."

O'Malley, best known for CBS' "Yes, Dear," will play a co-worker of Christian Slater's in the show. Elsewhere, Andrea Anders ("The Class") has signed on to an ABC comedy from writer Victor Fresco, according to The Hollywood Reporter.

"My Own Worst Enemy" stars Slater, in his first starring role in a TV series, as a suburban husband and father who discovers he has an alter ego, that of a ruthless superspy. He's apparently not the only one living a double life: O'Malley's character is described as a friend and co-worker of Slater's who doubles as a "brusque and violent" agent. The show is scheduled for a fall premiere.

O'Malley starred on "Yes, Dear" for six seasons. He co-stars in the George Clooney film "Leatherheads" and has appeared on several episodes of "My Name Is Earl."

The Fresco comedy at ABC centers on a guy who tries to do good things from within the large, amoral corporation where he works. Anders' credits also include "Joey" and "The Stepford Wives."