Olivia Wilde and Kal Penn lead new additions

After its third season finale hinted at a major cast shake-up, "House" has cast a quintet of potential fresh faces.

Olivia Wilde, Kal Penn, Peter Jacobson, Anne Dudek and Edi Gathegi will appear on "House" this fall, though it remains to be seen how long each of the actors will stick around.

When last we left the brilliant, but prickly Dr. House (Hugh Laurie), all three members of his previously stable team (House's "condos" or "cottages" in online parlance) had departed. Dr. Eric Foreman (Oman Epps) had quit to avoid becoming like House. Then, saying that the young doctor had learned everything he could in his fellowship, House fired Dr. Robert Chase (Jesse Spencer). Finally, feeling like her decision wouldn't change House's life anyway, Dr. Allison Cameron (Jennifer Morrison) also quit. But at least House got a new guitar.

Although the characters played by Epps, Spencer and Morrison may have fled the fold, all three actors are expected back this season.

When "House" kicks off again on Tuesday, Sept. 25, the titular character will be looking for new doctors for his fellowship program, which brings us to Wilde, Penn, Jacobson, Dudek and Gathegi.

Wilde is a FOX casting favorite, having done tours of duty on "Skin" and "The O.C." Her latest credits are NBC's short-lived "The Black Donnellys" and the feature "Alpha Dog."

Penn appeared on four episodes of "24" last season and also did the pilot "The Call" for ABC this past development run. His feature credits include this spring's "The Namesake" as well as "Harold & Kumar Go to White Castle" and its upcoming sequel.

Jacobson was one of the co-stars of FOX's "Method & Red" during its brief 2004 run. His other TV credits include "In Justice" and "Law & Order," while he can also currently be seen on the big screen in the "Transformers" film.

Dudek has been seen in "Big Day" and "Bones," while Gathegi appeared on "Lincoln Heights" and has a supporting role in the upcoming feature "Gone Baby Gone."