James Gandolfini, "The Sopranos" (HBO)

This is Gandolfini's sixth nomination. He won for Outstanding Lead Actor In A Drama Series for "The Sopranos" in 2000, 2001 and 2003.  
 
 
 


Hugh Laurie, "House" (FOX)

This is Laurie's second nomination.  
 


Denis Leary, "Rescue Me" (FX)

This is Leary's third nomination.  
 


James Spader, "Boston Legal" (FOX)

This is Spader's third nomination. He won Outstanding Lead Actor In A Drama Series for "The Practice" in 2004 and Outstanding Lead Actor In A Drama Series for "Boston Legal" in 2005.  
 

Kiefer Sutherland, "24" (FOX)

This is Sutherland's tenth nomination. He won Outstanding Lead Actor In A Drama Series for "24" in 2006. "24" won Outstanding Drama Series that year.